GNN reported earlier this month that from March 2nd to March 3rd, people from around the world booked 61,000 nights in Ukrainian cities via Airbnb, likely not one ever planning to check-in, or reschedule.
It was part of a creative social media campaign to channel funds into besieged cities where something like aid drops or supply trucks can’t reach, and saw $1.9 million raised for Ukrainians in just 48 hours.
Since that day, booking of Airbnbs across Ukraine has continued, with 434,000 rooms reserved and $15 million raised.
“We are so humbled by the inspiring generosity of our community during this moment of crisis,” said Haven Thorn, a company spokesperson. The company’s CEO also responded on Twitter.
One week later, 434,000 nights have been booked. That’s $15M going to Hosts in Ukraine
Apart from this clever fundraising, the past two weeks have seen Airbnb.org, the business’s non-profit wing, receive more than $5.2 million in small-dollar, direct donations from a total of more than 59,000 individual donors across 92 countries.
Airbnb was also quick to announce it would be setting up temporary housing for 100,000 Ukrainian refugees across Europe and North America.
Airbnb hosts have answered this generosity with their own, and more than 21,000 individuals have signed up to open their Airbnb-listed properties to Ukrainians, including 14,000 across Europe and 4,000 in the U.S.
The Utah Jazz Foundation is also partnering with Airbnb.org to provide more than 32,200 nights of temporary housing to refugees fleeing Ukraine, a number representing exactly 200% of the capacity of their Vivint Arena home stadium.
“I cannot begin to express my thanks to the Utah Jazz Foundation for their support of Airbnb.org’s work,” said Joe Gebbia, Airbnb co-founder and chairman of Airbnb.org.
In order to ensure a more comfortable stay, and to place less strain on their clients, a total of $16,625,000 has been contributed to an aid fund to help pay for these refugees’ lodgings, food, and other necessities by Airbnb employees and its co-founders, one of whom appeared on Ellen DeGeneres to announce an additional $10 million matching donation.
They said they were inspired by the reaction from their community and wanted to do their part.
Airbnb hosts that want to help need only register on the Airbnb.org Help Ukraine page.
SHARE This Inspiring Story From Ukraine With Others…
In 1857, a steam boat was going down in a storm off the coast of South Carolina. Loaded with more gold than had ever been placed onto a boat, the passengers chose to take photographs of family and loved ones before taking their chance with Davy Jones.
Thank to a recent expedition, dozens of these 150-year-old glass pane photographs have been recovered, putting a face on the SS Central America‘s unfortunates.
If the Titanic was the “Ship of Dreams,” Central America was the “Ship of Gold,” and of her 425 lost souls, most were miners returning from California gold fields wealthy beyond their wildest dreams.
Dr. Sean Kingsley, a British maritime archaeologist, was financed by private investors who have been trying to recover the treasure for more than 30 years, to dive down a mile and a half off the coast of South Carolina and retrieve what he could.
He partnered with Odyssey Marine Expeditions to make the dive, and the Kingsley co-wrote a paper on the discovery with an Odyssey scientist.
These tintype photos—daguerreotypes and ambrotypes—are kinds of wet collodion photography, and consist of panes of glass coated in chemicals. Ambrotypes produced a negative image that could be seen in front of black material, while daguerreotypes produced positive images visible when backlit.
“When you look at the actual faces of people, it takes you right there. You are looking at folks who lived it, and they’re just like us, although the clothing and fashions have changed,” Dr. Kingsley told The Guardian.
One individual he called the ‘Mona Lisa of the Depths’ is a young woman whose image is startlingly, almost eerily preserved. She stands with a quarter-smile, bare shoulders, swathed in jewels and lace.
The wreck and the tintypes are there to be seen in the magazine managed and published by Dr. Kingsley called Wreckwatch.
“This is the largest cache of early photographs found at sea, and unpublished until now. It’s a once-in-a-lifetime experience to actually see faces from the deep,” he said.
The SS Central America sank off South Carolina in 1857 with the loss of 425 lives. Dr Kingsley is focusing attention on a collection of glass plate photos that preserved the faces of miners,merchants &their families,staring up at the living from the seabed https://t.co/gyf7Z7Kipapic.twitter.com/MlhPKTcR2m
153 people are believed to have survived; mostly women and children who filled up the lifeboats. Of the other 425, The Wreckwatch review includes the words of one survivor.
“A great many of the passengers were miners, having considerable sums of gold about them, the product of years of toil. But the love of gold was forgotten in the anxiety and terror of the moment and many a man unbuckled his gold-stuffed belt and flung his hard-earned treasure upon the deck, some hoping to lighten their weight, and thus more easily keep themselves afloat, while others threw it away in despair, thinking there was no use for it in the watery grave they were going to.”
SHARE This Story From South Carolina in Those Social Feeds…
Quote of the Day: “Whether I drink often or just once in a while; I’m always sure to raise a glass to the dear old Emerald Isle.” – Pat Maloney (Happy St. Patrick’s Day!)
Photo by: (above) Jeff Hart, CC license; (below) Grafvision, Fotolia license
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Geri and Anthony return to podcasting, talking about changes for GNN, a new podcast called Livin’ Good Currency, and our favorite good news stories of the week… Recorded on March 11, 2022.
When marine biologists subjected two of the most common coral species to a +2°C aquarium for two years, mother nature showed she may just have a trick or two yet up her sleeves.
Keeping the planet from warming 2°C over the next thirty years has become somewhat of a mantra, especially when it comes to discussing vulnerable coral reefs in warming oceans, but the new experiment sheds light on potential adaptations scientists hadn’t foreseen.
Planning the longest coral resilience experiment ever done, coral expert Rowan McLachlan and her colleagues used a hammer and chisel to take samples of common corals from the reefs around Oahu, Hawai’i.
Rice coral, finger coral, and lobe coral were then transported into a 35-gallon aquarium on Coconut Island filled with sand, rubble, fish, and plankton, before being left outside to experience similar weather conditions as they would if they were under water.
“Porites compressa (finger coral) and Porites lobata (lobe coral) had the highest survivorship and coped well under future ocean conditions with positive calcification and increased biomass, maintenance of lipids, and the capacity to exceed their metabolic demand through photosynthesis and heterotrophy,” McLachlan et al. wrote in their corresponding paper on the experiment, published in Nature.
“We saw this long-term arc where you see stress responses, but after long enough there was acclimatization,” Andréa Grottoli, a coral biogeochemist at Ohio State who was senior author of the paper, told National Geographic. “They weren’t just struggling. Two of the three species were doing really well.”
Interestingly, reef monitors in Hawai’i also told National Geographic that the experiment jived with what they are observing in the corals around the islands, adding that if they can be protected from pollution and other man-made disturbances, they should be able to survive in the coming decades.
It’s good news for reefs around the world, since lobe coral is a pioneer species, and often the first kind of coral to begin building a reef. Finger coral too is not only found in Hawai’i but throughout the reefs in the Indian and Pacific Oceans.
They could act as decent species for coral reef restoration projects, a yet-unexplored potential way to mitigate coral loss by actively expanding their populations, an option that a decade ago would probably not have been taken, Grottoli admits.
FWC Fish and Wildlife Research Institute - CC license
FWC Fish and Wildlife Research Institute – CC license
A breeding ground for green turtles has seen a 500 percent boom in the numbers of clutches of eggs laid since hunting them was banned.
Scientists say the great conservation success story shows how numbers can slowly recover after killing the turtles was outlawed on Aldabra Atoll in the Seychelles in 1968.
Back thenm around 2,000-3,000 clutches of eggs were laid a year—a figure that stands at 12,000-15,000 in the last data from 2019.
And with Aldabra’s turtle population still being well below estimated pre-exploitation population numbers, the increase is likely to continue.
A team from Exeter University analyzed the figures provided by researchers from the Seychelles Islands Foundation.
Study lead author Adam Pritchard, from the Centre for Ecology and Conservation on Exeter’s Penryn Campus in Cornwall, said, “Green turtles have suffered massive historical population declines due to intensive harvesting of nesting females
“Aldabra Atoll was the first green turtle nesting site to be protected in the Western Indian Ocean, with a ban on turtle capture in 1968, followed by continued long-term monitoring by Seychelles Islands Foundation researchers.”
Professor Brendan Godley, who helped supervise the research, added, “It’s been an honour to support the analysis of the decades of work by the Seychelles team.
“The ongoing population increase of Aldabra’s green turtles is testament to long-term protection, and offers some clear evidence of the fact that we can be optimistic about marine conservation, well enacted.”
The study’s results reveal that green turtle clutches have increased at Aldabra by 2.6% per year overall, with the greatest increase at Settlement Beach on Picard, where exploitation of nesting females was historically the most intense.
Cheryl Sanchez, co-author of the study, published in the journal Endangered Species Research, who is currently doing a PhD on Aldabra’s turtles, said, “This study demonstrates the importance of long-term monitoring, which is often seen as less glamorous and valuable than targeted research.
“It has taken decades of tireless commitment to collect the data to confirm this increase, and the foresight to protect the nesting population before it was too late.
“Aldabra’s green turtles should continue to be an incredible conservation success story that we can follow for decades to come.”
The study’s figures confirm Aldabra as the second-largest monitored green turtle rookery in the region.
The research also shows the considerable contribution of Aldabra to regional green turtle numbers and clearly demonstrates the benefits of long-term protection and monitoring.
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A meta-analysis of more than half a million people has shown that a truly bare minimum of strength training can confer enormous benefit.
Researchers in Japan discovered that 30-60 minutes per week of muscle strengthening activities such as yoga, lifting weights, or gardening can reduce the risk of death from all causes by 10-20%.
When combined with aerobic exercise such as running, cycling, or swimming, this benefit was seen to rise to the 40 percentiles.
16 studies were looked at in the analysis. They consisted of more than half-a-million healthy adults being monitored for a period of at least twi years. The age range went from 18-97, and the monitoring period from 2-25 years.
All-cause mortality was looked at separately from heart disease and cancer, both of which tended to fall between 10-20%.
Reporting on the findings, published in the British Journal of Sports Medicine, the Guardian noted that muscle strengthening activity doesn’t have to involve grunting over kettle and bar bells, but carrying children long enough, pushing a wheelchair, carrying shopping bags, heavy gardening, doing body weight exercises like pushups, squats, or sit-ups, or working with resistance bands.
There was an L-shaped curve, showing that extending strength training by more than an hour slowly tapered off its effectiveness in fighting disease and mortality rates. Moderate to intense physical activity is already recommended at about 150 minutes per week, a generally-recognized minimum to build and maintain healthy skeleto-muscular function.
Extending strength training beyond 60 minutes per week has other health benefits not-related to death, heart disease, and cancer.
It increases BDNF, a neurotransmitter in the brain key for proper hormonal function and memory, it clears stress hormones while releasing endorphins, fights off the onset of Alzheimer’s, Parkinson’s, and other neurodegenerative diseases, it builds lean muscle mass, which itself is a predictor for disease, morbidity, and injury risk, and more.
The authors recognized limitations of the study, mainly that it relied on data from English-speaking countries. Greater diversity of participants would better flush out the research.
EMBARGOED UTIL 00.01 GMT MON MARCH 14
Bronze medal macro - White tufted worms by Michal Štros from the Czech Republic. See SWNS story SWNNunderwater. From a crocodile's toothy grin to a pouting fish the size of pea some of the best underwater pictures in the world have been revealed in a top competition. More than 1,200 pictures were entered for the 2021 underwaterphotography.com contest across 10 categories - from macro to sharks. The winner of the gold medal in the over/under category is this smiling crocodile in Cuba by Italian Massimo Giorgetta taken in Garden of the Queen, a protected area on an archipelago on the south of the island.Fellow Italian Raffaele Livornese won the wide angle/marine life category with this beautifully composed shot of two sealions playing whilst hunting on a school of sardines.
From a crocodile’s toothy grin to a pouting fish the size of pea, some of the world’s best underwater pictures have been revealed in a top competition.
More than 1,200 pictures were entered for the 2021 underwaterphotography.com contest across 10 categories, from Macro Photography to Sharks.
The winner of the gold medal in the Over/Under category is this smiling crocodile in Cuba by Italian Massimo Giorgetta, taken in Garden of the Queen, a protected area on an archipelago on the south of the island.
SWNS
Fellow Italian Raffaele Livornese won the Wide Angle/Marine Life category with this beautifully composed shot of two sea lions playing whilst hunting on a school of sardines in La Paz, Mexico.
SWNS
This tiny juvenile pouting trunkfish was only the size of a pea but snapper Leslie Howell from the US bagged a bronze in the Macro-Swimming category.
SWNS
She said, “This juvenile trunkfish was about the size of a pea. It was pretty active, darting in and out of the coral head, but it finally settled down enough for me to get this shot head on.”
No underwater photo competition would be complete without a good shark and a Great Hammerhead at Tiger Bay, Bahamas by German Reinhard Arndt was enough to bag him a gold medal.
But there was still beauty to be had in the tiny as these delicate white tufted worms billowing in the current got a bronze in the macro not swimming category for Czech Republic snapper Michal Štros.
White tufted worms by Michal Štros, SWNS
Website owner Tal Mor, who runs the competition, said, “It has been a difficult couple of years for dive and travel, yet the competition has still received a total of 1,283 entries.
“This photography contest is the longest running and one of the most prestigious online. A panel of judges select the best images entered in an online photo contest from the previous year.
“Gold, silver, and bronze medals are awarded for the top three from each category in order of merit.
SWNS
“Many other internationally acclaimed photographers have launched their photo careers here over the years.
Quote of the Day: “I started to trust… Just because I didn’t know how to “fix” my life, didn’t mean I wouldn’t be led.” – Tama Kieves
Photo by: Ian Britton, CC license
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Two-thirds of Brits admit to loving the mood boost they get when doing something environmentally conscious, according to a new survey.
A poll of 2,000 adults found they take pride when buying products that reduce their impact on the environment, and when washing out tubs to reuse them—as well as disposing of food waste in their very own compost bin.
Half also get a buzz from taking a ‘bag for life’ to the shops with them, while spirits are lifted for one in three when ditching single-use wipes in favor of reusable ones.
And two in five are making more effort to visit zero-waste shops to refill old bottles and pots with produce, instead of buying it in packaging.
The survey was commissioned by household cleaning brand Ecover to mark the launch of the Ecover Refillery—a reused petrol station fighting plastic waste with refills.
Tom Domen, Ecover’s global head of long-term innovation, said, “A small change can make a big difference.
“The simple act of refilling a plastic bottle can make you feel good, while also reducing the amount of plastic waste sent to landfill.
“That’s why we urge you to choose to reuse and join the ‘refillution’ by opting for refillable, reusable household products where you can use the packaging over and over and over.”
The poll also found 41 percent think the government should be doing more to make refilling as accessible as recycling.
And one in five want to make refilling their products and pantries a priority for the year ahead.
In fact, over half (53 percent) would use ‘refill’ shops more if they had one closer to home, while more refillable stations in mainstream supermarkets would make 62 percent more likely to reuse rather than recycle.
But millions of Brits are already making valuable swaps—including refilling water bottles, reusable coffee cups, and opting for reusable bags.
Ecover’s Tom Domen added, “Refill stations are becoming increasingly common across the country, and a simple search will tell you where your local store is.
“By the end of 2022, we aim to help people refill their Ecover bottles over three million times in the UK—which would be the equivalent of one refill every 10 seconds.
“Just remember that plastic can last a lifetime, so let’s all put it to work.”
The Ecover Refillery will be open to the public for two days:23rd March (10am – 7pm) and 24th March (9am – 7pm), at 69 Borough Road in London.
TOP 20 ENVIRONMENTALLY FRIENDLY ACTIVITIES TO PUT BRITS IN A GOOD MOOD:
1. Taking a reusable bag shopping
2. Turning lights off when not in use
3. Reusing food leftovers
4. Washing out plastic containers and recycling them
5. Turning things off at the socket when not in use
6. Using a reusable water bottle
7. Turning down the heating/using the heating less often
8. Washing out packaging/ plastic bottles to reuse them
9. Cycling or walking instead of driving somewhere
10. Washing clothes at 30 degrees
11. Using a food container instead of clingfilm or foil
12. Using reusable cloths instead of single-use wipes
13. Eating less meat
14. Washing clothes less often
15. Disposing of food waste in compost
16. Upcycling or repairing items and clothes to give them a second life
17. Shopping for plastic packaging-free fruit and/or veg
18. Buying second-hand items
19. Buying eco-friendly products
20. Putting leftover food into a compost bin
As physicists work in the nuclear fusion sector to unlock limitless clean energy through harnessing the power of the sun, they inadvertently invented a tool that could allow geothermal plants to deliver limitless clean energy by harnessing the power of the Earth.
That tool is a large millimeter-wave laser drill that will allow engineers to bore down more than 12.4 miles (20 km) into the Earth’s crust to harness the heat from the planet’s core.
Another link to nuclear fusion is that this laser drilling technology is being pioneered by a spin-off company called Quaise from MIT who also run a nuclear fusion reactor in Massachusetts.
The bottom line is that this idea is not science fiction, and Quaise has the money to put several full-scale demonstration machines into action by 2024, and hopes to have a 100- megawatt supercritical geothermal plant in operation by 2026.
At 12.4 miles into the Earth’s crust, temperatures soar to 500°C, a sector-redefining level compared to traditional drill bit borehole temperatures of around 200°C. At this stage and depth, water under the ground becomes “supercritical,” a state of matter where it’s neither a gas nor a liquid.
“A power plant that uses supercritical water as the working fluid can extract up to 10 times more useful energy from each drop when compared to non-supercritical plants,” a spokesperson from Quaise told New Atlas. “Aiming for supercritical conditions is key to attaining power densities consistent with fossil fuels.”
A recycling masterclass
It’s perhaps ironic that humans would seek to harness the energy of the sun and stars in a nuclear fusion reactor when there is 20 billion times more heat under our feet than the entire world’s energy consumption. Merely 0.03% of global energy is delivered from geothermal despite this richness.
A virtually limitless supply of energy exists in the form of this supercritical fluid snaking its way through the crust and mantle of the planet, and just 0.01% of it would provide far more wattage than the world uses.
In order to reach it though, we need better drilling technology, and Quaise is taking advantage of the work put into a 1970s piece of technology called a gyrotron. When needing to heat water into a plasma at the heart of a nuclear fusion reactor, scientists need to generate between 90-150 million degrees Celsius of heat. This has been done by both lasers and super magnets.
The gyrotron is one of those lasers, and it generates electromagnetic waves in the millimeter-wave spectrum, shorter than microwaves and longer than infrared or visible light. Designed, invented, and tested in the USSR, the device is excellent at rapidly heating up a plasma without substantial energy usage.
So, accessing already existing energy with already existing technology, Quaise has proved itself remarkably efficient. They’ve raised $63 million in funding—a pittance in the field of nuclear fusion, but they’re looking to cut out fossil fuels in a real way before the end of the decade.
Their next planned step may be the greatest recycling trick in the industry. As coal-fired power plants continue to be shuttered around the world, their giant, already established infrastructure for converting steam into electricity, large electricity distribution equipment, and talented workforce could simply be taken over by Quaise, who could merely replace the coal-fired components with those meant for harnessing supercritical water.
Pure futurism
“There are somewhere upwards of 8,500 coal-fired power plants around the world, totaling over 2,000 gigawatts of capacity, and they’ll all have to find something else to do by 2050,” writes Loz Blain at New Atlas.
Blain argues this is perhaps more revolutionary than nuclear fusion, and the beauty of the design, if it works, is that the technology originally made for fusion reactors could end up putting them out of a job.
Fusion reaction needs a bare-minimum of a decade more development before it can be deployed commercially. The financial investment needed over that time will also be substantial.
At 12-15 miles below the Earth’s surface, it doesn’t matter where the drill or ex-coal plant is located, the heat will be pretty much the same.
Tens of countries that are now struggling to advance into greener energy sources wouldn’t have to make the transition, which means hundreds of millions of acres of land saved from needing to be covered with wind turbines and solar panels, which produce huge amounts of e-waste, and don’t generate electricity if the weather conditions aren’t suitable.
In fact, the world would be set for a paradigm shift. Since unlimited clean energy could be obtained within most nations, it would untether them from geo-political concerns about oil-rich countries and their human rights abuses. On land and sea, birds and wildlife would be untouched by any massive polluting oil spills that would become a thing of the past.
(WATCH the video for this story below.)
POWER Up Those Feeds With News of This Energy Breakthrough…
The world’s first portable battery pack to recharge an electric vehicle (EV) will be shipping to customers in early 2023.
The ZipCharge Go was designed like a rolling suitcase and meant to address the fact that hundreds of millions of people might want an EV, but live in a building with street parking and therefore no way to recharge their EV at night.
An inability to charge near or at home is one of the main reasons to reject EVs in the UK. According to research, 38% of participants said they were not likely to buy an EV in the next five years, with 36% worried about being unable to charge at home.
With state-of-the art bi-directional charging, the Go can be filled up in one’s house in a single hour, while providing 20-40 miles of extra range in between 30-60 minutes when plugged into one’s car.
20-40 doesn’t sound like much, but neither did the mileage numbers for the early EVs, and the company will look to improve these numbers as soon as the product launches in 2023.
“Since our launch at COP26 in November last year, ZipCharge has received an unprecedented level of interest from potential customers around the world,” said ZipCharge co-founder Jonathan Carrier. “They immediately see the benefit of the Go portable charger to deliver low cost, convenient charging anywhere they park.”
Carrier and fellow co-founder Richie Sibal haa 40+ years of experiences working in the EV departments for automobile companies like Jaguar Land Rover, Lotus, and McLaren. ZipCharge Go will come with a mobile app that will allow people to track the charging speed and status of their battery.
This will allow users to plug in, go back inside, and see exactly how much time is left to full charge while they make a nice cuppa’, or anything else. This, the owners believe, will be ideal for delivery or service fleet managers, who can monitor the the battery state of all their vehicles in the field, avoid unnecessary stops to recharge, as well as inconvenient parking to charge up back in the depot.
Pricing will be around the same as a high-speed home EV charging station, or available for lease at £49 ($63) per month. However, GNN can confirm that the charging pack will not be available in a leather briefcase, removing the ability for Go owners to pretend they’re spies.
“We are committed to launching a truly ground-breaking product in the Go, one that meets the needs of a range of customer groups, and how they would like to use the Go,” Carrier says. “This includes private individuals, fleets and end-destinations, such as hotels, retail complexes, supermarkets and leisure activities – all locations where the ZipCharge Go can provide flexible, convenient and low-cost charging for everyone, anywhere they park.”
Bismack Biyombo, returning to the NBA after a year as a free agent, has announced he will donate the entire $1.3 million value of his contract to the construction of a hospital in his home town in Congo.
Taking last season off to care for his sick father, who passed away in August of 2021, Biyombo said he became aware of just how fortunate he was simply to be able to bring his father to the hospital.
The announcement was made last Friday, two months after Biyombo signed a one-year contract with the Phoenix Suns.
The construction will be carried out through the Bismack Biyombo Foundation, which uses the star’s success as an NBA player to help those in the DR Congo. During the early pandemic, the Foundation delivered $1 million in medical supplies to hospitals across the country.
The Foundation focuses on creating initiatives in three areas to multiply opportunities for children in the DRC: athletics, education, and health. Its work results in 185 annually-granted scholarships, 150 higher education opportunities, and helps over a thousand patients every week receive treatment at Congolese hospitals.
“I told my agent my salary for this year would be going to the construction of a hospital back home to give hope to the hopeless,” Miyombo said in an interview released on his Foundation’s YouTube channel. “I want to be able to give them better conditions so that they can somewhat have hope that their loved ones will be able to live and see another day.
The hospital will be named in honor of the man whom Miyombo described as “my friend, my business partner, my mentor, and everything.”
The story is remarkably similar to that of Atlanta Hawks center Dikembe Mutombo, who donated $2 million of his NBA earnings toward the building of a planned $44 million hospital and medical center in his home town of Kinshasa, Congo in 1998. GNN reported that the donation was made through the Dikemebe Mutombo Foundation.
”I’ve had an opportunity to live very well here in America—and to succeed,” said Mutombo. “But my success would be pointless if I forgot to look back at where I came from and help those who are still struggling for basic medical care.”
Quote of the Day: “The illiterate of the 21st century will not be those who cannot read and write, but those who cannot learn, unlearn, and relearn.” – Alvin Toffler
Photo by: Aaron Burden
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Joy Milne and Professor Perdita Barran – University of Manchester
Joy Milne and Professor Perdita Barran – University of Manchester
A couple of years ago, a woman named Joy Milne made headlines when scientists discovered that she could “smell” Parkinson’s disease on people with the neurodegenerative disorder.
Since then, researchers have been trying to build devices that could diagnose the disease through odor compounds on the skin.
Now, researchers reporting in ACS Omega have developed a portable, artificially intelligent olfactory system, or “e-nose,” that could someday diagnose the disease in a doctor’s office.
Parkinson’s disease (PD) causes motor symptoms, such as tremors, rigidity, and trouble walking, as well as non-motor symptoms, including depression and dementia.
Although there’s no cure, early diagnosis and treatment can improve one’s quality of life, relieve symptoms and prolong survival.
However, the disease usually isn’t identified until patients develop motor symptoms, and by that time, they’ve already experienced irreversible neuron loss.
Recently, scientists discovered that people with PD secrete increased sebum (an oily, waxy substance produced by the skin’s sebaceous glands), along with increased production of yeast, enzymes, and hormones, which combine to produce certain odors.
Human “super smellers” like Milne are very rare; she first caught scent of the disease’s “musky, oily odor” when she smelled it on her now-late husband Les. 12 years after she first detected the smell, as GNN reported, he was diagnosed with Parkinson’s at the age of 45.
Now researchers have used gas chromatography (GC)-mass spectrometry to analyze odor compounds in the sebum of people with PD. But the instruments are bulky, slow, and expensive. Jun Liu, Xing Chen and colleagues wanted to develop a fast, easy to use, portable, and inexpensive GC system to diagnose PD through smell, making it suitable for point-of-care testing.
The researchers developed an e-nose, combining GC with a surface acoustic wave sensor—which measures gaseous compounds through their interaction with a sound wave—and machine learning algorithms. The team collected sebum samples from 31 PD patients and 32 healthy controls by swabbing their upper backs with gauze.
They analyzed volatile organic compounds emanating from the gauze with the e-nose, finding three odor compounds (octanal, hexyl acetate, and perillic aldehyde) that were significantly different between the two groups, which they used to build a model for PD diagnosis.
Next, the researchers analyzed sebum from an additional 12 PD patients and 12 healthy controls, finding that the model had an accuracy of 70.8% in predicting PD. The model was 91.7% sensitive in identifying true PD patients, but its specificity was only 50%, indicating a high rate of false positives. When machine learning algorithms were used to analyze the entire odor profile, the accuracy of diagnosis improved to 79.2%.
Before the e-nose is ready for the clinic, the team needs to test it on many more people to improve the accuracy of the models, and they also need to consider factors such as race, the researchers say.
One of the grand challenges with using CRISPR-based gene editing on humans is that the molecular machinery sometimes makes changes to the wrong section of a host’s genome, creating the possibility that an attempt to repair a genetic mutation in one spot in the genome could accidentally create a dangerous new mutation in another.
But now, scientists at The University of Texas at Austin have redesigned a key component of a widely used CRISPR-based gene-editing tool, called Cas9, to be thousands of times less likely to target the wrong stretch of DNA while remaining just as efficient as the original version, making it potentially much safer.
“This really could be a game changer in terms of a wider application of the CRISPR Cas systems in gene editing,” said Kenneth Johnson, a professor of molecular biosciences and co-senior author of the study with David Taylor, an assistant professor of molecular biosciences. The paper’s co-first authors are postdoctoral fellows Jack Bravo and Mu-Sen Liu.
Other labs have redesigned Cas9 to reduce off-target interactions, but so far, all these versions improve accuracy by sacrificing speed. SuperFi-Cas9, as this new version has been dubbed, is 4,000 times less likely to cut off-target sites but just as fast as naturally occurring Cas9. Bravo says you can think of the different lab-generated versions of Cas9 as different models of self-driving cars. Most models are really safe, but they have a top speed of 10 miles per hour.
“They’re safer than the naturally occurring Cas9, but it comes at a big cost: They’re going extremely slowly,” said Bravo. “SuperFi-Cas9 is like a self-driving car that has been engineered to be extremely safe, but it can still go at full speed.”
So far, the researchers have demonstrated the use of SuperFi-Cas9 on DNA in test tubes. They’re now collaborating with other researchers who plan to test SuperFi-Cas9 for gene editing in living cells. They’re also working to develop still safer and more active versions of Cas9.
CRISPR-based gene-editing tools are adapted from naturally occurring systems in bacteria. In nature, a Cas9 protein floats around in the environment, searching for DNA with a very specific sequence of 20 letters, like the X on a pirate map that indicates “dig here.” Sometimes, when most of the letters are correct, except those in spots 18 through 20, Cas9 still goes ahead and digs in. This is called a mismatch, and it can have disastrous consequences in gene editing.
Taylor and Johnson developed a technique called kinetics-guided structure determination that used a cryo-electron microscope in the Sauer Structural Biology Lab to take snapshots of Cas9 in action as it interacted with this mismatched DNA.
They were surprised to discover that when Cas9 encounters this type of mismatch in positions 18 through 20, instead of giving up and moving on, it has a finger-like structure that swoops in and holds on to the DNA, making it act as if it were the correct sequence. Normally, a mismatch leaves the DNA a bit floppy; this finger-like structure stabilizes it.
“It’s like if you had a chair and one of the legs was snapped off and you just duct taped it together again,” Bravo said. “It could still function as a chair, but it might be a bit wobbly. It’s a pretty dirty fix.
Without that added stability in the DNA, Cas9 doesn’t take the other steps needed to cut the DNA and make edits. No one had ever observed this extra finger doing this stabilization before.
“This was something that I could never have, in a million years, imagined in my mind would have happened,” Taylor said.
Based on this insight, they redesigned the extra finger on Cas9 so that instead of stabilizing the part of the DNA containing the mismatch, the finger is instead pushed away from the DNA, which prevents Cas9 from continuing the process of cutting and editing the DNA. The result is SuperFi-Cas9, a protein that cuts the right target just as readily as naturally occurring Cas9, but is much less likely to cut the wrong target.
Other authors are Grace Hibshman, Tyler Dangerfield, Kyungseok Jung and Ryan McCool, also of The University of Texas at Austin.
Bravo, Liu, Hibshman, Dangerfield, Johnson, and Taylor are inventors on a patent application covering novel Cas9 designs based on this work. The UT Austin Office of Technology Commercialization is managing the intellectual property and working to find industry partners that can help realize the vast potential of the technology.
A group of whale sharks were recently seen feeding on baitfish balls in tandem with other predators in some stunning underwater footage.
The world’s largest fish normally cruises around expending very little energy while eating tiny krill, and this sort of fast coordinated hunting is very poorly understood by marine biologists.
Recorded growing as long as 60 feet and weighing many tons, despite a 5-foot-long mouth, its throat opening is only about the size of a grapefruit. This limits the animal’s available edibles to krill and plankton, but 21st-century documentation has confirmed that anchovies, baitfish, and even the occasional squid are also on the menu.
“Bait balls” are swarms of small fish concentrated in a single ever-moving mass as a defence mechanism. They draw in predators of all shapes, and in the video filmed off Ningaloo Reef in Western Australia, the whale sharks feed together with diving wedge-tailed shearwaters, which are a kind of petrel, powerful tuna, and both trevally and whaler sharks.
It seems possible that either the smaller feeders are coordinating their attacks off of the lumbering charges of the whale sharks, but cooperation in nature is rarely a single lane road, and it’s possible that the whale sharks benefit from the other predators’ presence as well.
“The interactions made my mind race with a whole bunch of questions,” Emily Lester, a postdoctoral fellow at the Australian Institute of Marine Science, told National Geographic. Lester published a paper on the interactions in the journal Pacific Conservation Biology.
“We know that when bait balls are around, other predators do these spatially-coordinated attacks to maximize their foraging efficiency. What if the same thing is happening here?”
“I wonder if this is a two-way interaction,” Lester muses. “After the whale sharks charge through the bait ball, can those other predators capitalize on the isolated fishes that are separated?”
Bait balls form, not as what seems to be an apparent suicide pact, but because not only is there strength in numbers, but also because the limitless number of targets confuses predators, which, possessing strong focal vision, prefer to focus on a single prey animal.
At 0:37 in the video, one can see that the charging whale shark is tailed by a cool dozen other hungry fish, perhaps ready to target the isolated fish as Lester suspected. What the whale sharks get in return is unknown.
(WATCH the video for this story below.)
FLOAT This Amazing Video to Your School of Friends on Social Media…
It’s sometimes said that “wisdom oft comes from the mouths of babes,” but what it doesn’t mention is that you have to dial 1 first.
A new telephone hotline is relieving stress and uplifting callers with laughter, words of encouragement, and advice from elementary school students—and it’s ringing off the hook.
The Peptoc Hotline was the brainchild of local art teacher Jessica Martin, who figured she would create some smiles in the Healdsburg, California community. But shortly after launching, it exploded into life—regularly receiving 300-400 calls per hour.
After calling the number 707-998-8410, voices of kids from West Side Elementary will direct the caller in either Spanish or English through the directory to find what topic they need to get through the day.
“I was moved by the incredible collection of advice and encouragement they gleaned, and how easily and distinctly they were able to communicate it,” Martin told CNN.
“If you’re feeling mad, frustrated or nervous, press 1,” says the directory. One of the suggestions you’d hear after being transferred is a student saying, “If you’re feeling mad you should take three deep breaths and think of things that make you happy.”
“If you need a pep talk from Kindergarteners, press 3… If you need to hear kids laughing with delight, press 4,” the directory continues. Voice recordings from pupils ages 5-12 include this gem: “If you’re feeling up high and unbalanced, think of groundhogs.”
On March 6th, a GoFundMe campaign was launched in response to the avalanche of 11,000 callers every hour! It raised $26,000 to keep the youthful advice flowing.
It was Martin’s own 6-year-old son that came up with the name, after she asked him to use his block letter toys to create a flyer for the hotline.
Her only piece of advice is that the name would include the phrase “pep talk,” forgetting that this is a very different thing when sounded out by a 6-year-old, who quickly named the hotline “Peptoc” which was charming enough on its own to settle the task.
The hotline will continue for the rest of the school year, reports CNN, and it will surely bring delight to many.
The Lesson: How can we ensure that we get the most out of education? What will be the future of primary healthcare? What is the most logical way of looking at failure, disappointment, or disaster? How can we reverse our biological age? Serial entrepreneur Naveen Jain gives his perspective on how to plan and execute a more harmonious future.
Notable Excerpt: “We are thinking backward as we’re educating our children. This idea that you develop one skill and you stay in your lane has to go away, because the whole education system was designed for the industrial era, where you learned to do machining and could work for the rest of your life. As we are living in this society today where the technologies are becoming obsolete by the time you even graduate, you have to learn to learn, you have to create children that are constantly learning.”
The Guest: Naveen Jain became an entrepreneur and philanthropist after leaving the higher echelons of Microsoft. He founded InfoSpace and Intelius, among others. Today, Jain is an executive and co-founder of Viome, a gut microbiome testing service (Read more about Viome in this GNN article). He’s also involved in Moon Express, a company aiming at lunar mining for elements like cobalt, niobium, and others.
At the moment, when you purchase Health Intelligence Test (Top Seller) or any other product from Viome, you will receive $20 off your first purchase by visiting https://viomehq.sjv.io/goodcurrency
Use Promo Code GOODCURRENCY and get an additional $20 off your order.
The Podcast: Livin’ Good Currency explores the relationship of time to our lives. It gives a simple, straight-forward formula that anyone can use to be present in the moment—and features a co-host who knows better than anyone the value of time (see below). How do you want to spend your life? This hour can inspire you, along with upcoming guests, to be sure you are ‘Livin’ Good Currency’ and never get caught running out of time.
Livin’ Good Currency cohosts Tony Samadani and Tobias Tubbs
The Hosts: Good News Network fans will know Tony (Anthony) Samadani as the co-owner of GNN and its Chief of Strategic Partnerships. Co-host Tobias Tubbs was handed a double life sentence without the possibility of parole for a crime he didn’t commit. Behind bars, he used his own version of the Livin’ Good Currency formula to inspire young men in prison to turn their hours into honors. An expert in conflict resolution, spirituality, and philosophy, Tobias is a master gardener who employs ex-felons to grow their Good Currency by planting crops and feeding neighborhoods.
Quote of the Day: “You never change things by fighting the existing reality. To change something, build a new model that makes the existing model obsolete.” – Buckminster Fuller
Photo by: Almos Bechtold
With a new inspirational quote every day, atop the perfect photo—collected and archived on our Quotes page—why not bookmark GNN.org for a daily uplift?